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Kossiakoff, Anthony

One or more keywords matched the following items that are connected to Kossiakoff, Anthony

Item Type	Name
Concept	Models, Molecular
Academic Article	Structural effects induced by mutagenesis affected by crystal packing factors: the structure of a 30-51 disulfide mutant of basic pancreatic trypsin inhibitor.
Academic Article	Hydroxyl and water molecule orientations in trypsin: comparison to molecular dynamic structures.
Academic Article	Crystallization and preliminary X-ray analysis of a 1:1 complex between a designed monomeric interferon-gamma and its soluble receptor.
Academic Article	Crystal structures of bovine chymotrypsin and trypsin complexed to the inhibitor domain of Alzheimer's amyloid beta-protein precursor (APPI) and basic pancreatic trypsin inhibitor (BPTI): engineering of inhibitors with altered specificities.
Academic Article	Human growth hormone and extracellular domain of its receptor: crystal structure of the complex.
Academic Article	Ternary complex between placental lactogen and the extracellular domain of the prolactin receptor.
Academic Article	Probing intermolecular backbone H-bonding in serine proteinase-protein inhibitor complexes.
Academic Article	Biosynthetic phage display: a novel protein engineering tool combining chemical and genetic diversity.
Academic Article	Analysis of solvent structure in proteins using neutron D2O-H2O solvent maps: pattern of primary and secondary hydration of trypsin.
Academic Article	High affinity RNase S-peptide variants obtained by phage display have a novel "hot-spot" of binding energy.
Academic Article	Structural basis for cytokine hormone-receptor recognition and receptor activation.
Academic Article	Solvent structure in crystals of trypsin determined by X-ray and neutron diffraction.
Academic Article	The 2.0 A structure of bovine interferon-gamma; assessment of the structural differences between species.
Academic Article	Structure of a phage display-derived variant of human growth hormone complexed to two copies of the extracellular domain of its receptor: evidence for strong structural coupling between receptor binding sites.
Academic Article	The structure and activity of a monomeric interferon-gamma:alpha-chain receptor signaling complex.
Academic Article	Site2 binding energetics of the regulatory step of growth hormone-induced receptor homodimerization.
Academic Article	The functional binding epitope of a high affinity variant of human growth hormone mapped by shotgun alanine-scanning mutagenesis: insights into the mechanisms responsible for improved affinity.
Academic Article	Structural effects induced by removal of a disulfide-bridge: the X-ray structure of the C30A/C51A mutant of basic pancreatic trypsin inhibitor at 1.6 A.
Academic Article	Neutron structure of subtilisin BPN': effects of chemical environment on hydrogen-bonding geometries and the pattern of hydrogen-deuterium exchange in secondary structure elements.
Academic Article	The crystal structure of Aq_328 from the hyperthermophilic bacteria Aquifex aeolicus shows an ancestral histone fold.
Academic Article	Structure of bistramide A-actin complex at a 1.35 angstroms resolution.
Academic Article	Dissecting the energetics of protein alpha-helix C-cap termination through chemical protein synthesis.
Academic Article	Crystal structure and site 1 binding energetics of human placental lactogen.
Academic Article	The 1.38 A crystal structure of DmsD protein from Salmonella typhimurium, a proofreading chaperone on the Tat pathway.
Academic Article	Role of a salt bridge in the model protein crambin explored by chemical protein synthesis: X-ray structure of a unique protein analogue, [V15A]crambin-alpha-carboxamide.
Academic Article	X-ray crystal structure of the protease inhibitor domain of Alzheimer's amyloid beta-protein precursor.
Academic Article	Comprehensive and quantitative mapping of energy landscapes for protein-protein interactions by rapid combinatorial scanning.
Academic Article	Time-controlled microfluidic seeding in nL-volume droplets to separate nucleation and growth stages of protein crystallization.
Academic Article	Exploring and designing protein function with restricted diversity.
Academic Article	Exploring the capacity of minimalist protein interfaces: interface energetics and affinity maturation to picomolar KD of a single-domain antibody with a flat paratope.
Academic Article	Mechanism of activation gating in the full-length KcsA K+ channel.
Academic Article	Understanding mechanisms governing protein-protein interactions from synthetic binding interfaces.
Academic Article	Intramolecular cooperativity in a protein binding site assessed by combinatorial shotgun scanning mutagenesis.
Academic Article	Tertiary structure is a principal determinant to protein deamidation.
Academic Article	Structure of bovine trypsinogen at 1.9 A resolution.
Academic Article	X-ray structure of native scorpion toxin BmBKTx1 by racemic protein crystallography using direct methods.
Academic Article	The X-ray structure of a growth hormone-prolactin receptor complex.
Academic Article	Crystal structure of full-length KcsA in its closed conformation.
Academic Article	Use of the neutron diffraction--H/D exchange technique to determine the conformational dynamics of trypsin.
Academic Article	X-ray structures of the antigen-binding domains from three variants of humanized anti-p185HER2 antibody 4D5 and comparison with molecular modeling.
Academic Article	The crystal structure of affinity-matured human growth hormone at 2 A resolution.
Academic Article	Allosteric control of ligand-binding affinity using engineered conformation-specific effector proteins.
Academic Article	Protein dynamics investigated by neutron diffraction.
Academic Article	Structure of the growth hormone-receptor complex and mechanism of receptor signaling.
Academic Article	Crystal structures of subtilisin BPN' variants containing disulfide bonds and cavities: concerted structural rearrangements induced by mutagenesis.
Academic Article	Molecular recognition in biological systems: from activation to inhibition.
Academic Article	Racemic crystallography of synthetic protein enantiomers used to determine the X-ray structure of plectasin by direct methods.
Academic Article	Direct determination of the protonation states of aspartic acid-102 and histidine-57 in the tetrahedral intermediate of the serine proteases: neutron structure of trypsin.
Academic Article	Mechanisms of zymogen activation.
Academic Article	Determination of the energetics governing the regulatory step in growth hormone-induced receptor homodimerization.
Academic Article	The structural basis for biological signaling, regulation, and specificity in the growth hormone-prolactin system of hormones and receptors.
Academic Article	The crystal structure of a quercetin 2,3-dioxygenase from Bacillus subtilis suggests modulation of enzyme activity by a change in the metal ion at the active site(s).
Academic Article	Principal determinants leading to transition state formation of a protein-protein complex, orientation trumps side-chain interactions.
Academic Article	A portable RNA sequence whose recognition by a synthetic antibody facilitates structural determination.
Academic Article	The three-dimensional structure of Bacillus amyloliquefaciens subtilisin at 1.8 A and an analysis of the structural consequences of peroxide inactivation.
Academic Article	The application of neutron crystallography to the study of dynamic and and hydration properties of proteins.
Academic Article	Protein dynamics investigated by the neutron diffraction-hydrogen exchange technique.
Academic Article	Structure of active ß-arrestin-1 bound to a G-protein-coupled receptor phosphopeptide.
Academic Article	Visualization of arrestin recruitment by a G-protein-coupled receptor.
Academic Article	Phage display selections for affinity reagents to membrane proteins in nanodiscs.
Academic Article	Structural mechanism of voltage-dependent gating in an isolated voltage-sensing domain.
Academic Article	Engineering Synthetic Antibody Inhibitors Specific for LD2 or LD4 Motifs of Paxillin.
Academic Article	A YidC-like Protein in the Archaeal Plasma Membrane.
Academic Article	Conformational Chaperones for Structural Studies of Membrane Proteins Using Antibody Phage Display with Nanodiscs.
Academic Article	A polar ring endows improved specificity to an antibody fragment.
Academic Article	Specific Recognition of a Single-Stranded RNA Sequence by a Synthetic Antibody Fragment.
Academic Article	The Preserved HTH-Docking Cleft of HIV-1 Integrase Is Functionally Critical.
Academic Article	Engineered synthetic antibodies as probes to quantify the energetic contributions of ligand binding to conformational changes in proteins.
Academic Article	Locking the Elbow: Improved Antibody Fab Fragments as Chaperones for Structure Determination.
Academic Article	Cryo-EM structure of human rhodopsin bound to an inhibitory G protein.
Academic Article	An engineered ultra-high affinity Fab-Protein G pair enables a modular antibody platform with multifunctional capability.
Academic Article	Development of "Plug and Play" Fiducial Marks for Structural Studies of GPCR Signaling Complexes by Single-Particle Cryo-EM.
Academic Article	Structure and drug resistance of the Plasmodium falciparum transporter PfCRT.
Academic Article	Structure and mechanism of the ER-based glucosyltransferase ALG6.
Academic Article	Synthetic antibodies against BRIL as universal fiducial marks for single-particle cryoEM structure determination of membrane proteins.
Academic Article	Recognition of an a-helical hairpin in P22 large terminase by a synthetic antibody fragment.
Academic Article	Structural basis of omega-3 fatty acid transport across the blood-brain barrier.
Academic Article	K29-linked ubiquitin signaling regulates proteotoxic stress response and cell cycle.
Academic Article	Structures of ABCB4 provide insight into phosphatidylcholine translocation.
Academic Article	Structure of an AMPK complex in an inactive, ATP-bound state.
Academic Article	Development of a universal nanobody-binding Fab module for fiducial-assisted cryo-EM studies of membrane proteins.

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